Smash Up: Monster Smash consists of four new factions for Smash Up: vampires, mad scientists, werewolves and giant ants. Tremble before the power of the ants!
-Vampires gain power as they destroy your opponents' minions
-Mad Scientists have released death in the form of powerful creations and can empower various minions
-Werewolves have explosive power to beat down opponents
-Giant Ants work as a great hive mind, spreading their power around as necessary to ensure their atomic-age victory

Smash Up: Monster Smash can be played on its own as a two-player game or combined with other Smash Up titles to allow for up to four players to compete at the same time.